Epitalon
Longevity peptide
Synthetic Tetrapeptide Bioregulator. Telomerase Activation, Cellular Longevity, Circadian Signaling systems & Pineal Peptide Research.
$39.00
In stock
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Research Data
Telomere Length Decline
Telomere integrity vs. age (% of peak)
Literature
Cellular Ratio
Biological Intersections
Relative pathway engagement
Activity Profile
Epitalon Longevity Profile
Mechanism
Cellular Pathway
01
Telomerase Gene Activation
Epitalon stimulates telomerase enzyme activity, enabling addition of TTAGGG repeats to telomere ends and counteracting replicative shortening in aging cells.
02
Pineal Gland Bioregulation
Modulates histone acetylation and methylation patterns, restoring youthful gene expression profiles in aged cells and tissues.
03
Tumor Suppression
Increases expression of superoxide dismutase (SOD) and catalase, reducing oxidative stress burden on telomeric DNA and genomic integrity.
Metabolic Network
Biosynthesis Map
Sequence Analysis
Amino Acid Sequence
Single-letter residue map colored by physicochemical property class. Hover any residue for full name and position.
A
L
A
G
L
U
A
S
P
G
L
Y
■ Hydrophobic
■ Polar
■ Positively Charged
■ Negatively Charged
■ Glycine
Research Focus
Telomere Maintenance Pathways
Sequential activation
Product Data
Compound Identity
| Product Name | Epitalon | Ala-Glu-Asp-Gly |
| Functional Class | Telomerase Activator |
| Form | Lyophilized |
| Purity | ≥98% |
| Content | 10mg |
| Count | 1 vial |
| Research Use | For in vitro and laboratory research use only. Not for human consumption. |
Specifications
Technical Specs
| CAS Number | 307297-39-8 |
| Molecular Weight | 390.35 g/mol |
| Molecular Formula | C14H22N4O9 |
| PubChem CID | 219042 |
| Appearance | White lyophilized powder |
| Storage | –20°C long-term / 2–8°C short-term |
Formulation Reference
Anatomy of a Peptide
A reference guide to the components of a lyophilized research peptide — from the active sequence to the excipients, solvents, buffers, and stabilizers used in formulation.
Active Peptide 2 items
Synthetic Amino Acid Sequence
The primary chain of amino acids synthesized via solid-phase peptide synthesis (SPPS). Defined by sequence length and molecular weight.
Peptide Modifications
Acetylation (N-terminus), amidation (C-terminus), PEGylation, or cyclization applied to improve stability, receptor binding, or half-life.
Excipients 4 items
Mannitol
Sugar alcohol bulking agent that forms an elegant lyophilized cake, aids reconstitution, and provides structural matrix during freeze-drying.
Trehalose
Non-reducing disaccharide that stabilizes peptide secondary structure by replacing water molecules through hydrogen bonding during dehydration.
Sucrose
Disaccharide used as a lyoprotectant and tonicity agent. Forms an amorphous glassy matrix that immobilizes the peptide and prevents aggregation.
Glycine
Amino acid bulking agent used in lyophilization. Crystallizes to provide mechanical strength to the freeze-dried cake structure.
Reconstitution Solvents 4 items
Bacteriostatic Water (BAC Water)
Sterile water containing 0.9% benzyl alcohol as a preservative. Preferred for multi-dose vials — inhibits microbial growth after initial puncture.
Sterile Water for Injection
USP-grade water, pyrogen-free, without preservatives. Used for single-dose preparations or when benzyl alcohol sensitivity is a concern.
Acetic Acid Solution (0.1–1%)
Dilute acid used for peptides with poor aqueous solubility at neutral pH. Protonates basic residues to improve dissolution.
Sodium Chloride 0.9%
Isotonic saline diluent. Provides physiological osmolality (~308 mOsm/L) and can improve stability of certain charged peptides.
Buffer Systems 4 items
Phosphate Buffered Saline (PBS)
Maintains pH 7.2–7.4. Composed of sodium phosphate dibasic, potassium phosphate monobasic, NaCl, and KCl. Mimics physiological ionic strength.
Acetate Buffer
Effective pH range 3.7–5.6. Composed of acetic acid and sodium acetate. Ideal for acidic peptides and those requiring lower pH for solubility.
Citrate Buffer
Effective pH range 3.0–6.2. Offers strong buffering capacity and metal-chelating properties. Used when oxidation-sensitive residues (Met, Cys) are present.
Histidine Buffer
Effective pH range 5.5–7.0. Low ionic strength, minimal interaction with peptides. Increasingly preferred in modern biopharmaceutical formulations.
Lyoprotectants & Cryoprotectants 3 items
Trehalose / Sucrose (Lyoprotectant)
Protect peptide conformation during the drying phase of lyophilization by forming hydrogen bonds that substitute for water molecules around the peptide.
Glycerol (Cryoprotectant)
Polyol that depresses the freezing point and reduces ice crystal formation, preventing mechanical damage to peptide structure during freezing steps.
Polyethylene Glycol (PEG)
Hydrophilic polymer that provides steric stabilization, reduces aggregation, and can serve as both cryoprotectant and solubility enhancer.
Preservatives & Antimicrobials 3 items
Benzyl Alcohol (0.9%)
Aromatic alcohol preservative in bacteriostatic water. Acts as antimicrobial agent by disrupting microbial cell membranes. Standard for multi-use vials.
Methyl / Propyl Parabens
Broad-spectrum antimicrobial preservatives effective against fungi and bacteria. Used in some peptide formulations where benzyl alcohol is incompatible.
Phenol (0.5%)
Bacteriostatic preservative used in certain injectable peptide formulations. Also acts as a conformational stabilizer for some peptide structures.
Counter Ions & Salt Forms 3 items
Trifluoroacetate (TFA)
Most common counter ion from RP-HPLC purification. Forms TFA salt with basic residues (Lys, Arg, His). May affect bioassay results and cell toxicity.
Acetate
Milder alternative to TFA obtained via ion exchange. Lower cytotoxicity, preferred for cell-based research assays and in vivo studies.
Hydrochloride (HCl)
Chloride salt form, sometimes used for improved stability or specific solubility profiles. Common in pharmaceutical-grade peptide preparations.
Chelating Agents 2 items
EDTA (Disodium)
Chelates divalent metal ions (Cu²⁺, Fe²⁺, Zn²⁺) that catalyze oxidative degradation of methionine and cysteine residues in peptides.
Citric Acid
Natural chelator with moderate metal-binding capacity. Dual function as buffer component and oxidation inhibitor in peptide formulations.
Antioxidants & Stabilizers 3 items
L-Methionine
Free methionine added as a sacrificial antioxidant. Preferentially oxidizes before methionine residues within the peptide chain.
Ascorbic Acid
Water-soluble antioxidant that scavenges reactive oxygen species. Used at low concentrations to prevent oxidative peptide degradation.
Polysorbate 20 / 80
Non-ionic surfactants that prevent surface adsorption and aggregation of peptides at air-liquid and container-liquid interfaces.
Preparation Tool
Reconstitution Calculator
Enter your target working concentration to calculate the exact solvent volume needed for this vial.
mg
Solvent Volume Required
—
Recommended solvents
Bacteriostatic Water
Sterile Water for Injection
Acetic Acid 0.1%
Sodium Chloride 0.9%
Product Specs
Solubility Profile
| Water | Highly soluble |
| Acidified Water | Highly soluble |
| DMSO | Highly soluble |
| Ethanol | Moderate |
| Lipid solvents | Poor compatibility |
Product Specs
Storage Specs
| Lyophilized | 2–8°C preferred |
| Long-term | −20°C recommended |
| Light Sensitivity | Moderate |
| Moisture | High sensitivity |
| Stability | Stable when dry |
| Container | Sterile sealed vial |
Literature
Research Citations
Catalogue Pathway
Related Systems
Use this for internal linking, adjacent products, and quick route-back buttons.
Important Notice
Research Use Only
AminoBox products are supplied for research, analytical, and laboratory use only. Product information is provided for educational and technical reference and does not constitute medical advice. Products are not intended to diagnose, treat, cure, or prevent any disease.
About This Data
Chart Explanation
What this chart is about
Research context
Research Outcome
Product Composition
| Property | Specification |
|---|---|
| Product Name | Epitalon |
| Alternate Names | Epithalon, Epithalone, AEDG Peptide |
| Peptide Content | 10mg |
| Peptide Class | Synthetic tetrapeptide |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Purity | Typically ≥99% |
| Research Category | Longevity & pineal peptide research |
Molecular Information
| Property | Specification |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 g/mol |
| CAS Number | 307297-39-8 |
| Peptide Length | 4 amino acids |
| Amino Acid Sequence | Ala–Glu–Asp–Gly (AEDG) |
| Compound Type | Synthetic bioregulatory peptide |
Structural Classification
| Category | Description |
| Compound Type | Synthetic tetrapeptide |
| Functional Class | Pineal bioregulatory peptide |
| Biological Focus | Circadian and cellular aging research |
| Mechanistic Focus | Telomerase and melatonin pathway research |
| Chemical Family | Short-chain peptide bioregulator |
Mechanism Research Profile
| Research Focus | Description |
| Telomerase Activity | Investigated for telomerase activation pathways |
| Cellular Senescence | Studied in aging and telomere biology models |
| Pineal Signaling | Explored for melatonin and circadian rhythm regulation |
| Oxidative Stress | Investigated in cellular stress response pathways |
| DNA Stability | Researched for genomic maintenance signaling |
Research Areas Commonly Associated
| Research Area | Focus |
| Longevity Biology | Cellular aging pathways |
| Circadian Rhythm Research | Pineal signaling and melatonin regulation |
| Telomere Biology | Telomerase and chromosomal stability |
| Cellular Resilience | Oxidative stress adaptation |
| Neuroendocrine Research | Age-related endocrine signaling |
Solubility Profile
| Solvent | Solubility |
| Water | Soluble |
| DMSO | Highly soluble |
| Ethanol | Limited solubility |
| Bacteriostatic Water | Compatible for reconstitution |
Storage Specifications
| Parameter | Recommendation |
| Lyophilized Storage | -20°C preferred |
| Reconstituted Storage | 2–8°C refrigerated |
| Light Sensitivity | Moderate |
| Moisture Sensitivity | High |
| Stability | Stable as dry lyophilized powder |
| Container Type | Sterile amber vial |
Technical Characteristics
| Feature | Notes |
| Delivery Format | Lyophilized peptide |
| Hydrophilicity | Highly hydrophilic |
| Net Charge at Physiological pH | Negative |
| Stability Profile | Susceptible to hydrolysis after reconstitution |
| Research Use | Laboratory research only |
Epitalon | 10mg | Synthetic Tetrapeptide Bioregulator
Epitalon (also known as Epithalon or Epithalone) is a synthetic tetrapeptide bioregulator originally developed from research surrounding naturally occurring peptide fractions isolated from the pineal gland.
Unlike stimulant-based metabolic compounds or hormonal agonists, Epitalon is studied primarily as a:
cellular signaling bioregulator peptide
with proposed effects occurring through modulation of:
- gene expression
- cellular repair systems
- chromosomal stability pathways
- neuroendocrine regulatory networks
Historical Scientific Background
Epitalon was developed from research conducted on:
- pineal gland peptide extracts
- neuroendocrine aging mechanisms
- peptide bioregulation systems
The pineal gland plays a major role in:
- circadian rhythm regulation
- melatonin secretion
- neuroendocrine signaling
- age-associated hormonal coordination
Researchers investigating pineal peptides proposed that specific short-chain peptides may influence:
- genomic stability
- cellular adaptation processes
- aging-associated transcriptional pathways
Epitalon emerged as one of the most studied synthetic analogs in this category.
Mechanism of Action
1. Telomerase Activation Research
Epitalon is most recognized for research involving:
telomerase regulation
Telomerase is an enzyme involved in:
- maintenance of telomeres
- chromosomal end protection
- cellular replication stability
Telomeres naturally shorten during repeated cellular division cycles, and this process is strongly associated with:
- cellular senescence
- genomic instability
- biological aging mechanisms
Experimental studies suggest Epitalon may influence:
- telomerase expression activity
- telomere maintenance pathways
- chromosomal protection systems
This is one of the primary reasons Epitalon gained attention in longevity science.
2. Cellular Senescence & Aging Biology
Cellular senescence refers to the progressive decline in cellular replication and repair capacity.
Epitalon is studied for possible interactions with:
- DNA stability systems
- oxidative stress resistance
- repair-associated transcription pathways
- cellular adaptation mechanisms
Research interest centers on whether peptide bioregulators can influence:
- healthy cellular aging
- tissue resilience
- genomic maintenance pathways
3. Pineal Gland & Circadian Signaling
Because Epitalon originated from pineal peptide research, it is also associated with:
- circadian rhythm regulation
- melatonin-related signaling
- neuroendocrine coordination
- sleep-wake cycle biology
The pineal gland functions as a central regulator of:
- biological timing systems
- hormonal synchronization
- oxidative stress adaptation
Researchers have explored whether peptide signaling molecules may help maintain these regulatory systems during aging.
4. Oxidative Stress & Cellular Protection
Oxidative stress contributes to:
- mitochondrial dysfunction
- DNA damage
- protein degradation
- accelerated cellular aging
Preclinical studies suggest Epitalon may influence:
- antioxidant enzyme activity
- free radical defense pathways
- cellular stress resistance systems
These mechanisms are commonly explored within:
- healthy aging research
- mitochondrial resilience studies
- longevity biology models
5. Gene Expression & Peptide Bioregulation
Short peptides such as Epitalon are studied for their ability to function as:
peptide bioregulators
This means they may influence:
- transcriptional signaling
- protein synthesis regulation
- cellular communication pathways
- tissue-specific gene expression
This area remains highly experimental but is central to peptide bioregulation science.
6. Longevity & Gerontology Research
Epitalon is widely associated with:
- gerontology research
- healthy aging science
- lifespan biology
- age-associated cellular decline studies
Its scientific significance stems from:
- telomere-related pathways
- genomic maintenance signaling
- neuroendocrine regulation
- oxidative resilience biology
Research Applications
Epitalon is commonly studied in:
- Telomerase activation research
- Cellular aging and senescence models
- Longevity and lifespan biology
- Pineal gland peptide studies
- Circadian rhythm research
- Oxidative stress adaptation models
- Neuroendocrine signaling systems
- Peptide bioregulation research
Scientific Significance
Epitalon is notable because it targets:
- upstream cellular aging mechanisms
rather than: - symptomatic metabolic stimulation
Its mechanisms are centered on:
- genomic maintenance
- peptide signaling
- telomere biology
- neuroendocrine regulation
- cellular resilience systems
Scientific Summary
Epitalon is best described as:
“A synthetic tetrapeptide bioregulator investigated for its interactions with telomerase activity, cellular aging pathways, pineal signaling, and genomic stability mechanisms.”
Epitalon Research Focus
Epitalon is primarily investigated for:
- modulation of telomerase activity
- regulation of telomere length maintenance
- peptide-based gene expression signaling
- pineal gland and circadian rhythm biology
- oxidative stress and aging pathways
Core Biological Pathways
Research suggests Epitalon may influence:
- chromosomal stability mechanisms
- cellular senescence pathways
- neuroendocrine regulation systems
- antioxidant defense signaling
- longevity-associated gene expression
Scientific Classification
Epitalon is best categorized as a synthetic tetrapeptide bioregulator studied in telomerase activation and cellular aging research.
Important Notice
This product is supplied strictly for:
- laboratory research
- analytical use
- scientific investigation purposes only
It is not intended for human consumption, medical use, or therapeutic application.
Epitalon is an investigational peptide compound studied primarily in cellular aging and peptide bioregulation research. All statements reflect experimental and mechanistic scientific literature only and do not constitute approved medical claims.
Scientific References – Epitalon (Epithalon) 10mg
| Ref # | Title | Journal | Focus | Link |
|---|---|---|---|---|
| 1 | Epitalon effects on telomerase activity and lifespan regulation | Biogerontology | Telomerase activation and aging biology | https://pubmed.ncbi.nlm.nih.gov/20160478/ |
| 2 | Pineal peptides and regulation of aging processes | Neuroendocrinology Letters | Pineal gland peptide bioregulators | https://pubmed.ncbi.nlm.nih.gov/16874727/ |
| 3 | Epithalon increases telomerase activity in human somatic cells | Bulletin of Experimental Biology and Medicine | Cellular aging and telomere biology | https://pubmed.ncbi.nlm.nih.gov/15242885/ |
| 4 | Peptide regulation of gene expression and chromatin stability | Biochemistry (Moscow) | Peptide bioregulation mechanisms | https://pubmed.ncbi.nlm.nih.gov/17970217/ |
| 5 | Role of telomerase in aging and age-related diseases | Nature Reviews Genetics | Telomere shortening and cellular senescence | https://pubmed.ncbi.nlm.nih.gov/15372105/ |
| 6 | Telomere biology and cellular aging mechanisms | Cell | Fundamental telomere science | https://pubmed.ncbi.nlm.nih.gov/12086608/ |
| 7 | Pineal gland peptides and circadian rhythm regulation | Journal of Pineal Research | Circadian and neuroendocrine signaling | https://pubmed.ncbi.nlm.nih.gov/21827480/ |
| 8 | Oxidative stress and aging: molecular mechanisms | Free Radical Biology & Medicine | Oxidative damage and aging pathways | https://pubmed.ncbi.nlm.nih.gov/17320152/ |
| 9 | Peptide bioregulators and gene expression modulation | Bulletin of Experimental Biology and Medicine | Russian peptide bioregulator theory | https://pubmed.ncbi.nlm.nih.gov/19799136/ |
| 10 | Telomerase activation and cellular longevity pathways | Aging Cell | Cellular lifespan regulation | https://pubmed.ncbi.nlm.nih.gov/19054392/ |
