buy melanotan 2 nasal spray
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Melanotan II Atomized Solution

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Melanotan II Nasal Spray is widely researched for producing tanned skin, energy homeostasis, and neuroendocrine signaling networks.

$54.00

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Form
Lyophilized
Molecular Formula
See COA
Molecular Weight
See COA
CAS Number
See COA
PubChem CID
See COA
Research Data
Primary Effect Over Time
Literature
Cellular Ratio
Comparative Metric
Activity Profile
Activity Profile
Mechanism
Cellular Pathway
01
MC4R → Central Sexual Arousal
02
MC1R → Melanogenesis and Pigmentation
03
MC3R → Energy Homeostasis and Anti-Inflammation
04
MC4R → Anorexigenic Signaling and Body Weight
05
Nasal Delivery Mechanism for Peptide Bioavailability
06
Bremelanotide (PT-141): MT-II Derivative Pathway to FDA Approval
Metabolic Network
Biosynthesis Map
MC4R → Central Sexual Arousal
MC1R → Melanogenesis and Pigmentation
MC3R → Energy Homeostasis and Anti-Inflammation
MC4R → Anorexigenic Signaling and Body Weight
Nasal Delivery Mechanism for Peptide Bioavailability
Bremelanotide (PT-141): MT-II Derivative Pathway to FDA Approval
 Melanotan II CENTRAL HUB
Sequence Analysis
Amino Acid Sequence
Single-letter residue map colored by physicochemical property class. Hover any residue for full name and position.
A C N L E C A S P H I S D P H E A R G T R P L Y S N H
27Residues
See COAMol. Weight
+2Net Charge
5Basic
3Acidic
■ Hydrophobic ■ Polar ■ Positively Charged ■ Negatively Charged ■ Glycine
Research Focus
Research Coverage
Product Data
Compound Identity
Product NameMelanotan II
Functional ClassPeptidics
FormLyophilized
Purity99%+
Content5mg
Count1 vial
Research UseResearch Grade
Specifications
Technical Specs
CAS NumberSee COA
Molecular WeightSee COA
Molecular FormulaSee COA
PubChem CIDSee COA
AppearanceWhite to off-white powder
Storage2-8C preferred
Formulation Reference
Anatomy of a Peptide
A reference guide to the components of a lyophilized research peptide — from the active sequence to the excipients, solvents, buffers, and stabilizers used in formulation.
Active Peptide 2 items
Synthetic Amino Acid Sequence
The primary chain of amino acids synthesized via solid-phase peptide synthesis (SPPS). Defined by sequence length and molecular weight.
Peptide Modifications
Acetylation (N-terminus), amidation (C-terminus), PEGylation, or cyclization applied to improve stability, receptor binding, or half-life.
Excipients 4 items
Mannitol
Sugar alcohol bulking agent that forms an elegant lyophilized cake, aids reconstitution, and provides structural matrix during freeze-drying.
Trehalose
Non-reducing disaccharide that stabilizes peptide secondary structure by replacing water molecules through hydrogen bonding during dehydration.
Sucrose
Disaccharide used as a lyoprotectant and tonicity agent. Forms an amorphous glassy matrix that immobilizes the peptide and prevents aggregation.
Glycine
Amino acid bulking agent used in lyophilization. Crystallizes to provide mechanical strength to the freeze-dried cake structure.
Reconstitution Solvents 4 items
Bacteriostatic Water (BAC Water)
Sterile water containing 0.9% benzyl alcohol as a preservative. Preferred for multi-dose vials — inhibits microbial growth after initial puncture.
Sterile Water for Injection
USP-grade water, pyrogen-free, without preservatives. Used for single-dose preparations or when benzyl alcohol sensitivity is a concern.
Acetic Acid Solution (0.1–1%)
Dilute acid used for peptides with poor aqueous solubility at neutral pH. Protonates basic residues to improve dissolution.
Sodium Chloride 0.9%
Isotonic saline diluent. Provides physiological osmolality (~308 mOsm/L) and can improve stability of certain charged peptides.
Buffer Systems 4 items
Phosphate Buffered Saline (PBS)
Maintains pH 7.2–7.4. Composed of sodium phosphate dibasic, potassium phosphate monobasic, NaCl, and KCl. Mimics physiological ionic strength.
Acetate Buffer
Effective pH range 3.7–5.6. Composed of acetic acid and sodium acetate. Ideal for acidic peptides and those requiring lower pH for solubility.
Citrate Buffer
Effective pH range 3.0–6.2. Offers strong buffering capacity and metal-chelating properties. Used when oxidation-sensitive residues (Met, Cys) are present.
Histidine Buffer
Effective pH range 5.5–7.0. Low ionic strength, minimal interaction with peptides. Increasingly preferred in modern biopharmaceutical formulations.
Lyoprotectants & Cryoprotectants 3 items
Trehalose / Sucrose (Lyoprotectant)
Protect peptide conformation during the drying phase of lyophilization by forming hydrogen bonds that substitute for water molecules around the peptide.
Glycerol (Cryoprotectant)
Polyol that depresses the freezing point and reduces ice crystal formation, preventing mechanical damage to peptide structure during freezing steps.
Polyethylene Glycol (PEG)
Hydrophilic polymer that provides steric stabilization, reduces aggregation, and can serve as both cryoprotectant and solubility enhancer.
Preservatives & Antimicrobials 3 items
Benzyl Alcohol (0.9%)
Aromatic alcohol preservative in bacteriostatic water. Acts as antimicrobial agent by disrupting microbial cell membranes. Standard for multi-use vials.
Methyl / Propyl Parabens
Broad-spectrum antimicrobial preservatives effective against fungi and bacteria. Used in some peptide formulations where benzyl alcohol is incompatible.
Phenol (0.5%)
Bacteriostatic preservative used in certain injectable peptide formulations. Also acts as a conformational stabilizer for some peptide structures.
Counter Ions & Salt Forms 3 items
Trifluoroacetate (TFA)
Most common counter ion from RP-HPLC purification. Forms TFA salt with basic residues (Lys, Arg, His). May affect bioassay results and cell toxicity.
Acetate
Milder alternative to TFA obtained via ion exchange. Lower cytotoxicity, preferred for cell-based research assays and in vivo studies.
Hydrochloride (HCl)
Chloride salt form, sometimes used for improved stability or specific solubility profiles. Common in pharmaceutical-grade peptide preparations.
Chelating Agents 2 items
EDTA (Disodium)
Chelates divalent metal ions (Cu²⁺, Fe²⁺, Zn²⁺) that catalyze oxidative degradation of methionine and cysteine residues in peptides.
Citric Acid
Natural chelator with moderate metal-binding capacity. Dual function as buffer component and oxidation inhibitor in peptide formulations.
Antioxidants & Stabilizers 3 items
L-Methionine
Free methionine added as a sacrificial antioxidant. Preferentially oxidizes before methionine residues within the peptide chain.
Ascorbic Acid
Water-soluble antioxidant that scavenges reactive oxygen species. Used at low concentrations to prevent oxidative peptide degradation.
Polysorbate 20 / 80
Non-ionic surfactants that prevent surface adsorption and aggregation of peptides at air-liquid and container-liquid interfaces.
Preparation Tool
Reconstitution Calculator
Enter your target working concentration to calculate the exact solvent volume needed for this vial.
mg
Recommended solvents
Bacteriostatic Water Sterile Water for Injection Acetic Acid 0.1% Sodium Chloride 0.9%
Product Specs
Solubility Profile
WaterHighly soluble
Acidified WaterHighly soluble
DMSOHighly soluble
EthanolModerate
Lipid solventsPoor compatibility
Product Specs
Storage Specs
Lyophilized2–8°C preferred
Long-term−20°C recommended
Light SensitivityModerate
MoistureHigh sensitivity
StabilityStable when dry
ContainerSterile sealed vial
Literature
Research Citations
[1]Wessells H, Levine N, Hadley ME, Dorr R, Hruby V. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000;12 Suppl 4:S74-79.
[2]Dorr RT, Lines R, Levine N, Brooks C, Xiang L, Hruby VJ, Hadley ME. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-1784.
[3]Ückert S, Bannowsky A, Albrecht K, Kuczyk MA. Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies. Expert Opin Investig Drugs. 2014;23(11):1477-1483.
[4]Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 2006;27(4):921-930.
[5]Ugwu SO, Blanchard J, Dorr RT, Levine N, Brooks C, Hadley ME, Aickin M, Hruby VJ. Skin pigmentation and pharmacokinetics of melanotan-I in humans. Biopharm Drug Dispos. 1997;18(3):259-269.
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Important Notice
Research Use Only

AminoBox products are supplied for research, analytical, and laboratory use only. Product information is provided for educational and technical reference and does not constitute medical advice. Products are not intended to diagnose, treat, cure, or prevent any disease.

Product Composition

Property Specification
Product Name

Melanotan II Nasal Spray
Alternate Names MT-II, Synthetic α-MSH analog
Peptide Content 10mg
Peptide Class Synthetic cyclic melanocortin peptide
Physical Form Lyophilized powder into nasal solution
Appearance White to off-white powder
Purity Typically ≥98%
Research Category Melanocortin receptor / pigmentation research

Molecular Information

Property Specification
Molecular Formula C50H69N15O9
Molecular Weight ~1024.2 g/mol
CAS Number 121062-08-6
PubChem CID 16132396
Peptide Configuration Cyclic heptapeptide
Sequence Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Compound Type Synthetic melanocortin receptor agonist

Structural Classification

Category Description
Compound Type Cyclic synthetic peptide
Functional Class Melanocortin receptor agonist
Biological Focus Pigmentation & energy regulation signaling
Mechanistic Focus MC1R, MC3R, MC4R, MC5R activation
Chemical Family α-MSH analog peptide

Mechanism Research Profile

Research Focus Description
Melanocortin Activation Studied for stimulation of MC1R pigmentation pathways
Melanin Production Investigated for eumelanin synthesis regulation
UV Response Modulation Research in UV-induced skin protective mechanisms
Appetite Regulation Studied via MC4R pathway interactions
Sexual Function Research Evaluated in melanocortin-linked signaling studies

Research Areas Commonly Associated

Research Area Focus
Pigmentation Biology Melanin synthesis pathways
Dermatological Research Skin photoprotection mechanisms
Endocrine Signaling Melanocortin system activity
Metabolic Regulation Appetite and energy balance pathways
Neurochemical Signaling MC4R-associated neural pathways

Solubility Profile

Solvent Solubility
Sterile Water Soluble
Bacteriostatic Water Compatible for reconstitution
DMSO Partially soluble
Buffered Solutions Compatible depending on pH
Saline Solution Generally compatible

Storage Specifications

Parameter Recommendation
Lyophilized Storage 2–8°C (refrigerated)
Long-term Storage -20°C preferred
Reconstituted Storage 2–8°C refrigerated
Light Sensitivity Moderate
Moisture Sensitivity High
Stability Stable in dry lyophilized state
Container Type Sterile sealed vial

Technical Characteristics

Feature Notes
Delivery Format Lyophilized peptide into nasal spray
Structural Advantage Cyclized structure improves receptor binding stability
Configuration Synthetic α-MSH analog peptide
Stability Profile Moderately stable; sensitive to heat and enzymatic degradation
Research Use Laboratory research only

Melanotan II Nasal Spray | 10mg (10mL) Peptide Solution

Research-Grade Melanocortin Receptor Agonist Formulation

Melanotan II Nasal Spray is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH) designed to interact with the melanocortin receptor system (MC1R–MC5R), a network of G-protein-coupled receptors involved in pigmentation, energy regulation, and neuroendocrine signaling.

It is structurally derived from the pro-opiomelanocortin (POMC) pathway, with targeted modifications that enhance receptor affinity and improve resistance to enzymatic degradation.

Unlike linear peptides that rapidly degrade in biological environments, Melanotan II Nasal Spray is conformationally stabilized through cyclization, which improves structural rigidity, receptor binding efficiency, and overall functional persistence.

Molecular & Structural Pharmacology

belongs to the melanocortin peptide family, a class of ligands that activate GPCR-based signaling pathways distributed across multiple physiological systems.

Its cyclic structure produces a pre-organized receptor-binding conformation, allowing stronger interaction with melanocortin receptors compared to endogenous α-MSH under equivalent concentrations.

This structural optimization enhances:

  • Receptor binding stability
  • Proteolytic resistance
  • Signal amplification efficiency

Melanotan II Nasal Spray Formulation Overview 

This product is a 10 mL isotonic intranasal solution containing 10 mg of Melanotan II, engineered for consistent spray dispersion and peptide stabilization.

Active Compound

Melanotan II — 10 mg total per 10 mL
Concentration: 1 mg/mL (1000 µg/mL)

Excipients & Functional Roles

Each component is selected to support peptide stability, mucosal compatibility, and delivery consistency:

Distilled water serves as the high-purity solvent base, minimizing ionic variability.
Glycerin improves viscosity, spray retention, and mucosal adhesion.
Sodium chloride maintains isotonic balance with nasal tissue (~0.9% physiological range).
Phenoxyethanol and ethylhexylglycerin provide antimicrobial protection while maintaining peptide compatibility.
Watermelon flavoring is included as an organoleptic masking agent to improve administration tolerance.

Together, this system supports stable solubility, uniform atomization, and reproducible dosing performance.

Melanotan II Nasal Spray Delivery & Spray Calibration

Because intranasal delivery depends on mechanical pump volume, dose accuracy is determined by actuation displacement.

At a concentration of 1 mg/mL, a standard 0.10 mL nasal spray actuation delivers:

~100 µg Melanotan II per spray (approximate, pump-dependent)

This makes dosing dependent on spray calibration and device output consistency, as is standard in metered nasal delivery systems.

Melanotan II Nasal Spray guide

Mechanism of Action (Melanocortin Signaling Pathway)

Melanotan II Nasal Spray acts as a non-selective melanocortin receptor agonist, with highest functional relevance at MC1R, the receptor most associated with melanogenesis regulation.

Upon receptor binding, it activates a canonical GPCR signaling cascade:

Receptor activation triggers Gs protein signaling, stimulating adenylyl cyclase and increasing intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), which phosphorylates downstream transcriptional regulators including MITF (microphthalmia-associated transcription factor).

MITF upregulation enhances expression of key melanogenic enzymes such as tyrosinase, TRP-1, and TRP-2, which collectively regulate melanin synthesis within melanocytes.

This results in amplification of endogenous pigmentation signaling pathways rather than direct enzymatic inhibition or structural alteration of melanocytes.

Melanotan II Nasal Spray and System-Wide Melanocortin Activity

The melanocortin receptor system extends beyond skin pigmentation and is also expressed in:

  • Hypothalamic energy regulation centers
  • Central nervous system appetite pathways
  • Neuroendocrine signaling circuits
  • Peripheral metabolic tissues

Because of this distribution, melanocortin agonists are studied in multiple physiological contexts beyond dermatological pigmentation research.

Peptide Stability & Structural Advantages of Melanotan II Nasal Spray

Melanotan II exhibits enhanced stability compared to endogenous melanocortins due to its cyclic structure, which reduces enzymatic breakdown and improves receptor interaction efficiency.

Key stability features include:

  • Cyclized backbone reducing proteolytic cleavage
  • Improved receptor-binding conformation
  • Reduced terminal degradation susceptibility
  • Balanced hydrophobic and hydrophilic interaction profile

These properties contribute to improved persistence in biological environments relative to linear peptide analogs.

Intranasal Delivery Characteristics

Intranasal administration is a non-invasive delivery route characterized by high vascular absorption potential and partial bypass of first-pass hepatic metabolism.

Absorption occurs primarily through:

  • Nasal epithelial diffusion pathways
  • Paracellular transport across tight junctions
  • Respiratory mucosa systemic uptake routes

This delivery system is widely studied for peptides due to its ability to support rapid systemic exposure without gastrointestinal degradation.

Mechanistic Summary of Melanotan II Nasal Spray

Melanotan II Nasal Spray functions as a:

  • Melanocortin GPCR agonist
  • cAMP pathway activator
  • MITF-mediated transcriptional regulator
  • Melanogenesis signaling amplifier

Its activity is based on signal pathway enhancement of endogenous biological processes, particularly within melanocortin-regulated systems.

Scientific Positioning

Melanotan II Nasal Sprayis a research-grade melanocortin receptor agonist peptide studied for its role in pigmentation signaling pathways, neuroendocrine receptor activity, and cyclic AMP-mediated transcriptional regulation.

Ref # Title Journal Focus Link
1 Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide analogue Life Sciences Melanogenesis and skin pigmentation induction https://nih.gov
2 Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction Journal of Urology MC4R activation and sexual stimulation properties https://nih.gov
3 Melanoma associated with the use of the synthetic melanocortin analogue melanotan-II Dermatology Melanocyte overstimulation risks and clinical observations https://nih.gov
4 Changes of melanocytic lesions induced by Melanotan Journal of the German Society of Dermatology UV tanning interactions, atypical nevi, and skin darkening https://nih.gov
5 Preformulation studies with melanotan-II: a potential skin cancer chemopreventive peptide Journal of Pharmaceutical Sciences Peptide stability, degradation pathways, and formulation physics https://nih.gov