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SNAP-8 | Acetyl Octapeptide-3

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Acetyl Octapeptide-3  to reduce the appearance of repetitive facial tension associated with crow’s feet, forehead lines, glabellar folds, and perioral creasing.

$57.00

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  • By purchasing any products, you acknowledge and agree that all materials are supplied solely for scientific research, laboratory experimentation, or analytical purposes.
Form
Lyophilized
Molecular Formula
See COA
Molecular Weight
See COA
CAS Number
See COA
PubChem CID
See COA
Research Data
Primary Effect Over Time
Literature
Cellular Ratio
Comparative Metric
Activity Profile
Activity Profile
Mechanism
Cellular Pathway
01
Extended SNAP-25 Displacement
02
Synergistic Combination with Leuphasyl
03
Expression Line Attenuation
Metabolic Network
Biosynthesis Map
Extended SNAP-25 Displacement
Synergistic Combination with Leuphasyl
Expression Line Attenuation
Signal Output
Response
Repair Systems
Stress
Mitochondria
Energy
 SNAP 8 ACETYL OCTAPEP... CENTRAL HUB
Sequence Analysis
Amino Acid Sequence
Single-letter residue map colored by physicochemical property class. Hover any residue for full name and position.
A C G L U G L U M E T G L N A R G A R G A L A A S P N H
28Residues
See COAMol. Weight
+2Net Charge
3Basic
1Acidic
■ Hydrophobic ■ Polar ■ Positively Charged ■ Negatively Charged ■ Glycine
Research Focus
Research Coverage
Product Data
Compound Identity
Product NameSNAP-8 | Acetyl Octapeptide-3
Functional ClassDermatics
FormLyophilized
Purity99%+
Content5mg
Count1 vial
Research UseResearch Grade
Specifications
Technical Specs
CAS NumberSee COA
Molecular WeightSee COA
Molecular FormulaSee COA
PubChem CIDSee COA
AppearanceWhite to off-white powder
Storage2-8C preferred
Formulation Reference
Anatomy of a Peptide
A reference guide to the components of a lyophilized research peptide — from the active sequence to the excipients, solvents, buffers, and stabilizers used in formulation.
Active Peptide 2 items
Synthetic Amino Acid Sequence
The primary chain of amino acids synthesized via solid-phase peptide synthesis (SPPS). Defined by sequence length and molecular weight.
Peptide Modifications
Acetylation (N-terminus), amidation (C-terminus), PEGylation, or cyclization applied to improve stability, receptor binding, or half-life.
Excipients 4 items
Mannitol
Sugar alcohol bulking agent that forms an elegant lyophilized cake, aids reconstitution, and provides structural matrix during freeze-drying.
Trehalose
Non-reducing disaccharide that stabilizes peptide secondary structure by replacing water molecules through hydrogen bonding during dehydration.
Sucrose
Disaccharide used as a lyoprotectant and tonicity agent. Forms an amorphous glassy matrix that immobilizes the peptide and prevents aggregation.
Glycine
Amino acid bulking agent used in lyophilization. Crystallizes to provide mechanical strength to the freeze-dried cake structure.
Reconstitution Solvents 4 items
Bacteriostatic Water (BAC Water)
Sterile water containing 0.9% benzyl alcohol as a preservative. Preferred for multi-dose vials — inhibits microbial growth after initial puncture.
Sterile Water for Injection
USP-grade water, pyrogen-free, without preservatives. Used for single-dose preparations or when benzyl alcohol sensitivity is a concern.
Acetic Acid Solution (0.1–1%)
Dilute acid used for peptides with poor aqueous solubility at neutral pH. Protonates basic residues to improve dissolution.
Sodium Chloride 0.9%
Isotonic saline diluent. Provides physiological osmolality (~308 mOsm/L) and can improve stability of certain charged peptides.
Buffer Systems 4 items
Phosphate Buffered Saline (PBS)
Maintains pH 7.2–7.4. Composed of sodium phosphate dibasic, potassium phosphate monobasic, NaCl, and KCl. Mimics physiological ionic strength.
Acetate Buffer
Effective pH range 3.7–5.6. Composed of acetic acid and sodium acetate. Ideal for acidic peptides and those requiring lower pH for solubility.
Citrate Buffer
Effective pH range 3.0–6.2. Offers strong buffering capacity and metal-chelating properties. Used when oxidation-sensitive residues (Met, Cys) are present.
Histidine Buffer
Effective pH range 5.5–7.0. Low ionic strength, minimal interaction with peptides. Increasingly preferred in modern biopharmaceutical formulations.
Lyoprotectants & Cryoprotectants 3 items
Trehalose / Sucrose (Lyoprotectant)
Protect peptide conformation during the drying phase of lyophilization by forming hydrogen bonds that substitute for water molecules around the peptide.
Glycerol (Cryoprotectant)
Polyol that depresses the freezing point and reduces ice crystal formation, preventing mechanical damage to peptide structure during freezing steps.
Polyethylene Glycol (PEG)
Hydrophilic polymer that provides steric stabilization, reduces aggregation, and can serve as both cryoprotectant and solubility enhancer.
Preservatives & Antimicrobials 3 items
Benzyl Alcohol (0.9%)
Aromatic alcohol preservative in bacteriostatic water. Acts as antimicrobial agent by disrupting microbial cell membranes. Standard for multi-use vials.
Methyl / Propyl Parabens
Broad-spectrum antimicrobial preservatives effective against fungi and bacteria. Used in some peptide formulations where benzyl alcohol is incompatible.
Phenol (0.5%)
Bacteriostatic preservative used in certain injectable peptide formulations. Also acts as a conformational stabilizer for some peptide structures.
Counter Ions & Salt Forms 3 items
Trifluoroacetate (TFA)
Most common counter ion from RP-HPLC purification. Forms TFA salt with basic residues (Lys, Arg, His). May affect bioassay results and cell toxicity.
Acetate
Milder alternative to TFA obtained via ion exchange. Lower cytotoxicity, preferred for cell-based research assays and in vivo studies.
Hydrochloride (HCl)
Chloride salt form, sometimes used for improved stability or specific solubility profiles. Common in pharmaceutical-grade peptide preparations.
Chelating Agents 2 items
EDTA (Disodium)
Chelates divalent metal ions (Cu²⁺, Fe²⁺, Zn²⁺) that catalyze oxidative degradation of methionine and cysteine residues in peptides.
Citric Acid
Natural chelator with moderate metal-binding capacity. Dual function as buffer component and oxidation inhibitor in peptide formulations.
Antioxidants & Stabilizers 3 items
L-Methionine
Free methionine added as a sacrificial antioxidant. Preferentially oxidizes before methionine residues within the peptide chain.
Ascorbic Acid
Water-soluble antioxidant that scavenges reactive oxygen species. Used at low concentrations to prevent oxidative peptide degradation.
Polysorbate 20 / 80
Non-ionic surfactants that prevent surface adsorption and aggregation of peptides at air-liquid and container-liquid interfaces.
Preparation Tool
Reconstitution Calculator
Enter your target working concentration to calculate the exact solvent volume needed for this vial.
mg
Recommended solvents
Bacteriostatic Water Sterile Water for Injection Acetic Acid 0.1% Sodium Chloride 0.9%
Product Specs
Solubility Profile
WaterHighly soluble
Acidified WaterHighly soluble
DMSOHighly soluble
EthanolModerate
Lipid solventsPoor compatibility
Product Specs
Storage Specs
Lyophilized2–8°C preferred
Long-term−20°C recommended
Light SensitivityModerate
MoistureHigh sensitivity
StabilityStable when dry
ContainerSterile sealed vial
Literature
Research Citations
[1]Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310.
[2]Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327-345.
[3]Pintea A, Manea A, Pintea C, et al. Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review. Biomolecules. 2025;15(1):88.
[4]Badilli U, Inal O. Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers. Polymers (Basel). 2025;17(6):798.
[5]Zdrada-Nowak J, Surgiel-Gemza A, Szatkowska M. Acetyl Hexapeptide-8 in Cosmeceuticals — A Review of Skin Permeability and Efficacy. Int J Mol Sci. 2025.
Catalogue Pathway
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Important Notice
Research Use Only

AminoBox products are supplied for research, analytical, and laboratory use only. Product information is provided for educational and technical reference and does not constitute medical advice. Products are not intended to diagnose, treat, cure, or prevent any disease.

Product Composition

Property Specification
Product Name Acetyl Octapeptide-3
Alternate Names SNAP-8, Acetyl Octapeptide-8
Content Amount 100 mg
Compound Class Synthetic acetylated octapeptide
Physical Form Lyophilized peptide powder
Appearance White to off-white powder
Purity Typically ≥98% (HPLC dependent)
Research Category Cosmetic peptide / neuromodulatory peptide research
Primary Function Expression-line and facial signaling peptide research

Molecular Information

Property Specification
Molecular Formula C41H70N16O16S
Molecular Weight ~1075.16 g/mol
CAS Number 868844-74-0
PubChem CID 86080331
INCI Name Acetyl Octapeptide-3
Peptide Sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Sequence Abbreviation EEMQRRAD
Compound Type Acetylated signaling octapeptide
Structural Classification SNAP-25 fragment analog

Structural Classification

Category Description
Compound Type Synthetic biomimetic octapeptide
Functional Class Neuromodulatory cosmetic peptide
Biological Focus Facial muscle signaling and expression line research
Mechanistic Focus SNARE complex modulation
Chemical Family Acetylated neuropeptide analogs
Structural Origin Extended analog of Argireline (Acetyl Hexapeptide-8)

Mechanism Research Profile

Research Focus Description
SNARE Complex Modulation Studied for interaction with SNAP-25 signaling pathways
Neurotransmitter Release Investigated for reduced vesicle fusion signaling
Expression Line Research Explored for softening repetitive facial contraction patterns
Facial Tension Modulation Cosmetic peptide research into localized neuromuscular activity
Topical Cosmetic Research Commonly formulated into cosmetic serums and peptide creams
Biomimetic Activity Mimics N-terminal SNAP-25 protein fragments

Research Areas Commonly Associated

Research Area Focus
Cosmetic Peptide Research Fine line and wrinkle appearance studies
Dermatological Research Expression line modulation
Neurocosmetic Research Neuromuscular signaling pathways
Peptide Delivery Research Topical peptide transport systems
Anti-Aging Research Dynamic wrinkle reduction research
Skin Science Surface neuromodulation and peptide formulation

Solubility Profile

Solvent Solubility
Water Soluble
Sterile Water Highly compatible
DMSO Soluble
Ethanol Limited stability
Glycols Good compatibility
Lipid Systems Moderate compatibility

Storage Specifications

Parameter Recommendation
Short-Term Storage 2–8°C
Long-Term Storage -20°C preferred
Light Sensitivity Moderate
Moisture Sensitivity High
Stability Stable in lyophilized form
Reconstituted Stability Refrigerate after mixing
Container Type Sealed amber peptide vial

Technical Characteristics

Feature Notes
Delivery Format Lyophilized peptide powder (100 mg)
Structural Advantage Extended peptide chain compared to Argireline
Bioactivity Profile Cosmetic neuromodulatory signaling peptide
Functional Target SNAP-25 / SNARE-associated pathways
Topical Research Use Commonly studied in cosmetic formulations
Stability Profile Stable when protected from moisture and heat
Research Use Laboratory and cosmetic research only

Buy SNAP-8 (Acetyl Octapeptide-3)

Mechanism of Action

SNAP-8 was specifically designed to mimic a fragment of SNAP-25 (Synaptosomal-Associated Protein 25), a critical component of the SNARE protein complex involved in synaptic vesicle fusion and acetylcholine release at the neuromuscular junction.

Under normal physiological conditions, acetylcholine is released from presynaptic neurons through the coordinated assembly of SNARE proteins:

  • SNAP-25
  • Syntaxin
  • VAMP/Synaptobrevin

This fusion process initiates muscular contraction, including the repeated micro-contractions responsible for expression wrinkles over time. SNAP-8 competitively interferes with SNARE complex assembly by mimicking portions of the SNAP-25 sequence, thereby attenuating neurotransmitter release involved in superficial facial muscle signaling.

The result is a gradual reduction in visible facial tension and dynamic wrinkle formation, producing a smoother and more relaxed skin appearance without inducing complete muscular paralysis associated with injectable neurotoxins.

Advanced Structural Engineering

Compared to traditional hexapeptide analogs, SNAP-8 incorporates two additional amino acids into its molecular architecture:

Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

This elongated sequence was engineered to improve binding affinity and increase competitive inhibition efficiency within the SNARE complex. Preclinical formulation research suggests enhanced catecholamine inhibition and improved wrinkle-softening potential compared to earlier-generation neurotransmitter-modulating peptides.

The peptide possesses a molecular weight of approximately 1075 Da and is commonly incorporated into advanced serums, emulsions, liposomal delivery systems, and peptide complexes targeting visible photoaging and repetitive-expression dermal stress.

Cosmetic Research Applications

SNAP-8 is extensively studied in cosmetic and dermatological formulation environments for its potential role in:

  • Expression line reduction
  • Forehead wrinkle softening
  • Crow’s feet appearance improvement
  • Periorbital smoothing systems
  • Dynamic wrinkle modulation
  • Advanced anti-aging peptide formulations
  • Multi-peptide rejuvenation protocols
  • Neuromodulatory cosmetic systems

Research literature and supplier-sponsored cosmetic studies have reported visible reductions in wrinkle depth and skin roughness following sustained topical application. Some formulation studies have demonstrated measurable improvements in expression-line appearance after approximately 28 days of consistent use.

Formulation Synergy

SNAP-8 is frequently combined with additional cosmetic actives to create comprehensive skin-rejuvenation systems. Common synergistic pairings include:

  • Matrixyl® peptides
  • Copper peptides (GHK-Cu)
  • Hyaluronic acid
  • Retinoid systems
  • Acetyl Hexapeptide-8
  • Growth factor complexes
  • Barrier-repair lipids
  • Biomimetic hydration technologies

Research discussions within cosmetic peptide communities suggest formulation quality, peptide concentration, and transdermal delivery systems significantly influence observable results.

Stability & Cosmetic Integration

SNAP-8 is typically utilized in water-based peptide serums, creams, gels, and microemulsion systems. Due to its peptide structure, formulation pH, preservative compatibility, and stabilization methodology are critical factors affecting peptide integrity and bioactivity.

Advanced encapsulation technologies such as liposomal delivery systems and nano-emulsions are frequently explored to improve dermal penetration and optimize topical performance.

Ingredient Specifications

Ingredient Name: Acetyl Octapeptide-3
Alternative Name: SNAP-8
Molecular Formula: C41H70N16O16S
Molecular Weight: 1075.16 g/mol
Peptide Length: 8 Amino Acids
Appearance: Lyophilized Powder
Research Category: Cosmetic Neuropeptide
Application Type: Topical Cosmetic Formulation Research Only

Important Disclaimer

This product is supplied strictly for cosmetic, laboratory, and research purposes only. Not intended to diagnose, treat, cure, or prevent any disease. Not for human consumption or injectable use. Cosmetic additive intended exclusively for formulation and research applications.

Reference Table

Reference Source Information Provided Link
PubChem Molecular formula, molecular weight, peptide sequence, identifiers https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-octapeptide-3
Peptide Protocol Wiki Molecular structure and sequence analysis https://www.peptideprotocolwiki.com/peptides/snap-8/molecule
PeptideInsight SNAP-25 mechanism overview and peptide background https://peptideinsight.com/peptides/snap-8
GLPBase Structural comparison with Argireline and cosmetic mechanism profile https://glpbase.com/aesthetic-medicine/snap8/
peptides.studio Molecular identifiers and sequence notation https://peptides.studio/snap-8
PubChem Alternative Registry Additional identifier and synonym references https://pubchem.ncbi.nlm.nih.gov/compound/86080331