5-Amino-1MQ
Synthetic quinolinium-based small molecule
5-Amino-1MQ studies in cellular energy metabolism, sirtuin activation, and DNA repair pathway support.
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Research Data
5-Amino-1MQ Decline
Intracellular pathway levels vs. age (% of peak)
Literature
Cellular Ratio
Biological Intersections
Relative pathway engagement
Activity Profile
5-Amino-1MQ Biochemical Profile
Mechanism
Cellular Pathway
01
Cellular Uptake & NNMT Binding
5-Amino-1MQ enters cells as a small cationic molecule and competitively inhibits NNMT, blocking nicotinamide methylation by SAMe.
02
NAD⁺ Precursor Preservation
By inhibiting NNMT-mediated nicotinamide clearance, 5-Amino-1MQ supports NAD+ salvage pathway availability and cellular NAD+ levels.
03
Methylation Economy & SAMe Sparing
Reducing NNMT activity conserves SAMe for cellular methylation processes, supporting epigenetic regulation and methyl group economy.
Metabolic Network
Biosynthesis Map
Sequence Analysis
Amino Acid Sequences
Single-letter residue map colored by physicochemical property class. Hover any residue for full name and position.
BPC-157
G
E
P
P
P
G
K
P
A
D
D
A
G
L
V
TB-500
L
K
K
T
E
T
Q
■ Hydrophobic
■ Polar
■ Positively Charged
■ Negatively Charged
■ Glycine
Research Focus
NNMT Inhibition Pathways
Sequential activation strength
Comparative Trend
Normalized Profile
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Product Data
Compound Identity
| Product Name | 5-Amino-1MQ |
| Functional Class | NNMT Inhibitor |
| Form | Lyophilized |
| Purity | 99% + |
| Content | 5mg |
| Count | 1 vial |
| Research Use | For in vitro and laboratory research use only. Not for human consumption. |
Specifications
Technical Specs
| CAS Number | 42464-96-0 |
| Molecular Weight | ~159.21 g/mol |
| Molecular Formula | C10H11N2+ |
| PubChem CID | 950107 |
| Appearance | White to off-white crystalline powder |
| Storage | 2–8°C short-term / –20°C long-term |
In Vitro Activity
NNMT Inhibition Curve
IC50 = 1 μM · Hill n = 1 · Assay model
Formulation Reference
Anatomy of a Peptide
A reference guide to the components of a lyophilized research peptide — from the active sequence to the excipients, solvents, buffers, and stabilizers used in formulation.
Active Peptide 2 items
Synthetic Amino Acid Sequence
The primary chain of amino acids synthesized via solid-phase peptide synthesis (SPPS). Defined by sequence length and molecular weight.
Peptide Modifications
Acetylation (N-terminus), amidation (C-terminus), PEGylation, or cyclization applied to improve stability, receptor binding, or half-life.
Excipients 4 items
Mannitol
Sugar alcohol bulking agent that forms an elegant lyophilized cake, aids reconstitution, and provides structural matrix during freeze-drying.
Trehalose
Non-reducing disaccharide that stabilizes peptide secondary structure by replacing water molecules through hydrogen bonding during dehydration.
Sucrose
Disaccharide used as a lyoprotectant and tonicity agent. Forms an amorphous glassy matrix that immobilizes the peptide and prevents aggregation.
Glycine
Amino acid bulking agent used in lyophilization. Crystallizes to provide mechanical strength to the freeze-dried cake structure.
Reconstitution Solvents 4 items
Bacteriostatic Water (BAC Water)
Sterile water containing 0.9% benzyl alcohol as a preservative. Preferred for multi-dose vials — inhibits microbial growth after initial puncture.
Sterile Water for Injection
USP-grade water, pyrogen-free, without preservatives. Used for single-dose preparations or when benzyl alcohol sensitivity is a concern.
Acetic Acid Solution (0.1–1%)
Dilute acid used for peptides with poor aqueous solubility at neutral pH. Protonates basic residues to improve dissolution.
Sodium Chloride 0.9%
Isotonic saline diluent. Provides physiological osmolality (~308 mOsm/L) and can improve stability of certain charged peptides.
Buffer Systems 4 items
Phosphate Buffered Saline (PBS)
Maintains pH 7.2–7.4. Composed of sodium phosphate dibasic, potassium phosphate monobasic, NaCl, and KCl. Mimics physiological ionic strength.
Acetate Buffer
Effective pH range 3.7–5.6. Composed of acetic acid and sodium acetate. Ideal for acidic peptides and those requiring lower pH for solubility.
Citrate Buffer
Effective pH range 3.0–6.2. Offers strong buffering capacity and metal-chelating properties. Used when oxidation-sensitive residues (Met, Cys) are present.
Histidine Buffer
Effective pH range 5.5–7.0. Low ionic strength, minimal interaction with peptides. Increasingly preferred in modern biopharmaceutical formulations.
Lyoprotectants & Cryoprotectants 3 items
Trehalose / Sucrose (Lyoprotectant)
Protect peptide conformation during the drying phase of lyophilization by forming hydrogen bonds that substitute for water molecules around the peptide.
Glycerol (Cryoprotectant)
Polyol that depresses the freezing point and reduces ice crystal formation, preventing mechanical damage to peptide structure during freezing steps.
Polyethylene Glycol (PEG)
Hydrophilic polymer that provides steric stabilization, reduces aggregation, and can serve as both cryoprotectant and solubility enhancer.
Preservatives & Antimicrobials 3 items
Benzyl Alcohol (0.9%)
Aromatic alcohol preservative in bacteriostatic water. Acts as antimicrobial agent by disrupting microbial cell membranes. Standard for multi-use vials.
Methyl / Propyl Parabens
Broad-spectrum antimicrobial preservatives effective against fungi and bacteria. Used in some peptide formulations where benzyl alcohol is incompatible.
Phenol (0.5%)
Bacteriostatic preservative used in certain injectable peptide formulations. Also acts as a conformational stabilizer for some peptide structures.
Counter Ions & Salt Forms 3 items
Trifluoroacetate (TFA)
Most common counter ion from RP-HPLC purification. Forms TFA salt with basic residues (Lys, Arg, His). May affect bioassay results and cell toxicity.
Acetate
Milder alternative to TFA obtained via ion exchange. Lower cytotoxicity, preferred for cell-based research assays and in vivo studies.
Hydrochloride (HCl)
Chloride salt form, sometimes used for improved stability or specific solubility profiles. Common in pharmaceutical-grade peptide preparations.
Chelating Agents 2 items
EDTA (Disodium)
Chelates divalent metal ions (Cu²⁺, Fe²⁺, Zn²⁺) that catalyze oxidative degradation of methionine and cysteine residues in peptides.
Citric Acid
Natural chelator with moderate metal-binding capacity. Dual function as buffer component and oxidation inhibitor in peptide formulations.
Antioxidants & Stabilizers 3 items
L-Methionine
Free methionine added as a sacrificial antioxidant. Preferentially oxidizes before methionine residues within the peptide chain.
Ascorbic Acid
Water-soluble antioxidant that scavenges reactive oxygen species. Used at low concentrations to prevent oxidative peptide degradation.
Polysorbate 20 / 80
Non-ionic surfactants that prevent surface adsorption and aggregation of peptides at air-liquid and container-liquid interfaces.
Preparation Tool
Reconstitution Calculator
Enter your target working concentration to calculate the exact solvent volume needed for this vial.
mg
Solvent Volume Required
—
Recommended solvents
Bacteriostatic Water
Sterile Water for Injection
Acetic Acid 0.1%
Sodium Chloride 0.9%
Product Specs
Solubility Profile
| Water | Highly soluble |
| Acidified Water | Highly soluble |
| DMSO | Highly soluble |
| Ethanol | Moderate |
| Lipid solvents | Poor compatibility |
Product Specs
Storage Specs
| Lyophilized | 2–8°C preferred |
| Long-term | −20°C recommended |
| Light Sensitivity | Moderate |
| Moisture | High sensitivity |
| Stability | Stable when dry |
| Container | Sterile sealed vial |
Literature
Research Citations
Catalogue Pathway
Related Systems
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Important Notice
Research Use Only
AminoBox products are supplied for research, analytical, and laboratory use only. Product information is provided for educational and technical reference and does not constitute medical advice. Products are not intended to diagnose, treat, cure, or prevent any disease.
About This Data
Chart Explanation
What this chart is about
Research context
Research Outcome
Selective investigational NNMT inhibitor studied across cellular methylation, NAD+ metabolism, adipocyte energy regulation, and mitochondrial efficiency research.
5MG_VIAL
LYOPHILIZED
RESEARCH_USE_ONLY
LYOPHILIZED
RESEARCH_USE_ONLY
Functional Class: NNMT inhibitor
Class:Quinolinium small molecule
TARGET: NNMT inhibition
PURITY: Typically ≥98%
STORAGE: 2–8°C preferred
PRODUCT COMPOSITION
| Property | Specification |
|---|---|
| Product Name | 5-Amino-1MQ |
| Alternate Names | 5-Amino-1-methylquinolinium, NNMT inhibitor |
| Content | 5mg |
| Package | Lyophilized vial format |
| Compound Class | Synthetic quinolinium-based small molecule |
| Physical Form | Lyophilized powder |
| Appearance | White to off-white crystalline powder |
| Research Cat. | Metabolic regulation / NNMT / NAD+ |
MOLECULAR DATA
| Property | Specification |
|---|---|
| Formula | C10H11N2+ (halide salt) |
| Mol. Weight | ~159.21 g/mol free base cation |
| CAS Number | 42464-96-0 |
| PubChem CID | 950107 |
| Compound Type | Quinolinium-derived small molecule |
| Stereochem. | Achiral |
NNMT INHIBITOR OVERVIEW
5-Amino-1MQ is a selective investigational inhibitor of nicotinamide N-methyltransferase — an enzyme governing methylation balance, nicotinamide utilization, and cellular energy regulation.
Targets intracellular metabolic regulation over stimulant or thermogenic pathways.
WHAT IS NNMT?
Cytosolic enzyme transferring methyl groups from SAMe to nicotinamide, producing 1-methylnicotinamide.
- Cellular methylation capacity
- NAD+ precursor availability
- Energy balance regulation
- Adipocyte metabolic programming
MECHANISM PROFILE
| Focus | Description |
|---|---|
| NNMT Inhibition | Reduces formation of 1-MNA |
| NAD+ Preservation | Limits nicotinamide clearance |
| Metabolic Reg. | Energy expenditure & adipose models |
| Mitochondrial | Supports NAD+-dependent pathways |
| Energy Balance | Metabolic flexibility models |
SCIENTIFIC SIGNIFICANCE
Targets upstream metabolic regulatory systems rather than downstream stimulant or thermogenic pathways.
- Intracellular metabolic programming
- Methylation economy regulation
- Adipocyte signaling pathways
- Cellular energy homeostasis
NAD+ & ENERGY SYSTEMS
NNMT is closely linked to NAD+ biology through nicotinamide metabolism and salvage pathways.
- Oxidative phosphorylation
- Sirtuin enzyme activation
- Mitochondrial biogenesis
- Cellular redox balance
ADIPOSE RESEARCH
NNMT expression elevated in obesity and metabolic dysfunction models — a compelling target in adipose biology and energy metabolism research.
- Fat cell energy expenditure
- Adipogenesis regulation
- Metabolic syndrome pathways
RESEARCH DOMAINS
| Domain | Focus |
|---|---|
| Metabolic Biology | NAD+ salvage, energy flux |
| Epigenetics | Methylation landscape |
| Longevity | NAD+-dependent sirtuins |
| Endocrine | Insulin sensitivity models |
STRUCTURAL CLASS
| Category | Description |
|---|---|
| Compound Type | Methylquinolinium derivative |
| Functional Class | NNMT inhibitor |
| Bio. Focus | NAD+ salvage & energy metabolism |
| Chem. Family | Pyridinium/quinolinium cationic |
SOLUBILITY PROFILE
| Solvent | Solubility |
|---|---|
| Water | Highly soluble |
| Acidified Water | Highly soluble |
| DMSO | Highly soluble |
| Ethanol | Moderate |
| Lipid solvents | Poor compatibility |
STORAGE SPECS
| Parameter | Recommendation |
|---|---|
| Lyophilized | 2–8°C preferred |
| Long-term | −20°C recommended |
| Light Sensitivity | Moderate |
| Moisture | High sensitivity |
| Stability | Stable when dry |
| Container | Sterile sealed vial |
TECHNICAL NOTES
| Feature | Notes |
|---|---|
| Delivery Format | Lyophilized powder, 5mg vial |
| Structural Adv. | Small cationic — efficient uptake |
| Bioactivity | NNMT inhibition & NAD+ modulation |
| Configuration | Synthetic quinolinium derivative |
| Stability | High stability when dry |
| Research Use | Laboratory research only |
CATALOGUE PATHWAY
CATALOGUE › PEPTIDES › METABOLIC_REG
These products connect 5-Amino-1MQ to related metabolic, NAD+, and mitochondrial research systems.
NAD+ PATHWAY
NAD+Related through NAD+ availability, cellular energy systems, and mitochondrial metabolism research.OPEN PRODUCT
NAD+Related through NAD+ availability, cellular energy systems, and mitochondrial metabolism research.OPEN PRODUCT
METABOLIC SIGNALLING
MOTS-CAdjacent research focus around mitochondrial signalling, metabolic flexibility, and energy regulation.OPEN PRODUCT
MOTS-CAdjacent research focus around mitochondrial signalling, metabolic flexibility, and energy regulation.OPEN PRODUCT
ENERGY EXPENDITURE
SLU-PP-332Connected through metabolic research, energy expenditure models, and cellular performance pathways.OPEN PRODUCT
SLU-PP-332Connected through metabolic research, energy expenditure models, and cellular performance pathways.OPEN PRODUCT
NAD+ PRECURSOR
JBSNF / NMNNAD+ precursor context and longevity-oriented cellular preservation research.OPEN PRODUCT
JBSNF / NMNNAD+ precursor context and longevity-oriented cellular preservation research.OPEN PRODUCT
5-AMINO-1MQ REFERENCE TABLE
| Category | Reference / Finding | Source |
|---|---|---|
| NNMT Enzyme Target | Selective, membrane-permeable inhibitor of nicotinamide N-methyltransferase. | PubMed |
| Metabolic Role | Regulates nicotinamide utilization, SAMe consumption, and NAD+ precursor availability. | Nature |
| NAD+ Metabolism | NNMT activity influences nicotinamide pools and NAD+ salvage pathway dynamics. | Cell Metabolism |
| Adipose Tissue | Elevated NNMT expression observed in obesity and adipose dysfunction models. | NCBI |
| Methylation | NNMT consumes SAMe, impacting cellular methylation capacity and epigenetic regulation. | NCBI |
| Mitochondrial | NNMT inhibition studied in relation to mitochondrial function and oxidative metabolism. | Nature |
| Metabolic Disease | NNMT implicated in obesity, insulin resistance, and metabolic syndrome pathways. | NCBI |
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IMPORTANT NOTICE
This product is supplied strictly for analytical and research purposes only. All statements reflect experimental and mechanistic research literature and do not constitute approved medical claims. Not intended to diagnose, treat, cure, or prevent any disease.
