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Biopeptide-EL | Palmitoyl Hexapeptide-12

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Biopeptide-EL is an advanced biomimetic lipopeptide engineered to support dermal matrix integrity, collagen signalling pathways, and visible skin rejuvenation.

$58.00

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  • By purchasing any products, you acknowledge and agree that all materials are supplied solely for scientific research, laboratory experimentation, or analytical purposes.
Form
Lyophilized
Molecular Formula
See COA
Molecular Weight
See COA
CAS Number
See COA
PubChem CID
See COA
Research Data
Primary Effect Over Time
Literature
Cellular Ratio
Comparative Metric
Activity Profile
Activity Profile
Mechanism
Cellular Pathway
01
Elastin Receptor-Mediated Chemotaxis
02
Elastin & ECM Gene Expression
03
Anti-inflammatory ECM Protection
Metabolic Network
Biosynthesis Map
Elastin Receptor-Mediated Chemotaxis
Elastin & ECM Gene Expression
Anti-inflammatory ECM Protection
Signal Output
Response
Repair Systems
Stress
Mitochondria
Energy
 BIOPEPTIDE EL CENTRAL HUB
Sequence Analysis
Amino Acid Sequence
Single-letter residue map colored by physicochemical property class. Hover any residue for full name and position.
P A L V G V A P G
9Residues
See COAMol. Weight
+0Net Charge
0Basic
0Acidic
■ Hydrophobic ■ Polar ■ Positively Charged ■ Negatively Charged ■ Glycine
Research Focus
Research Coverage
Product Data
Compound Identity
Product NameBiopeptide-EL | Palmitoyl Hexapeptide-12
Functional ClassDermatics
FormLyophilized
Purity99%+
Content5mg
Count1 vial
Research UseResearch Grade
Specifications
Technical Specs
CAS NumberSee COA
Molecular WeightSee COA
Molecular FormulaSee COA
PubChem CIDSee COA
AppearanceWhite to off-white powder
Storage2-8C preferred
Formulation Reference
Anatomy of a Peptide
A reference guide to the components of a lyophilized research peptide — from the active sequence to the excipients, solvents, buffers, and stabilizers used in formulation.
Active Peptide 2 items
Synthetic Amino Acid Sequence
The primary chain of amino acids synthesized via solid-phase peptide synthesis (SPPS). Defined by sequence length and molecular weight.
Peptide Modifications
Acetylation (N-terminus), amidation (C-terminus), PEGylation, or cyclization applied to improve stability, receptor binding, or half-life.
Excipients 4 items
Mannitol
Sugar alcohol bulking agent that forms an elegant lyophilized cake, aids reconstitution, and provides structural matrix during freeze-drying.
Trehalose
Non-reducing disaccharide that stabilizes peptide secondary structure by replacing water molecules through hydrogen bonding during dehydration.
Sucrose
Disaccharide used as a lyoprotectant and tonicity agent. Forms an amorphous glassy matrix that immobilizes the peptide and prevents aggregation.
Glycine
Amino acid bulking agent used in lyophilization. Crystallizes to provide mechanical strength to the freeze-dried cake structure.
Reconstitution Solvents 4 items
Bacteriostatic Water (BAC Water)
Sterile water containing 0.9% benzyl alcohol as a preservative. Preferred for multi-dose vials — inhibits microbial growth after initial puncture.
Sterile Water for Injection
USP-grade water, pyrogen-free, without preservatives. Used for single-dose preparations or when benzyl alcohol sensitivity is a concern.
Acetic Acid Solution (0.1–1%)
Dilute acid used for peptides with poor aqueous solubility at neutral pH. Protonates basic residues to improve dissolution.
Sodium Chloride 0.9%
Isotonic saline diluent. Provides physiological osmolality (~308 mOsm/L) and can improve stability of certain charged peptides.
Buffer Systems 4 items
Phosphate Buffered Saline (PBS)
Maintains pH 7.2–7.4. Composed of sodium phosphate dibasic, potassium phosphate monobasic, NaCl, and KCl. Mimics physiological ionic strength.
Acetate Buffer
Effective pH range 3.7–5.6. Composed of acetic acid and sodium acetate. Ideal for acidic peptides and those requiring lower pH for solubility.
Citrate Buffer
Effective pH range 3.0–6.2. Offers strong buffering capacity and metal-chelating properties. Used when oxidation-sensitive residues (Met, Cys) are present.
Histidine Buffer
Effective pH range 5.5–7.0. Low ionic strength, minimal interaction with peptides. Increasingly preferred in modern biopharmaceutical formulations.
Lyoprotectants & Cryoprotectants 3 items
Trehalose / Sucrose (Lyoprotectant)
Protect peptide conformation during the drying phase of lyophilization by forming hydrogen bonds that substitute for water molecules around the peptide.
Glycerol (Cryoprotectant)
Polyol that depresses the freezing point and reduces ice crystal formation, preventing mechanical damage to peptide structure during freezing steps.
Polyethylene Glycol (PEG)
Hydrophilic polymer that provides steric stabilization, reduces aggregation, and can serve as both cryoprotectant and solubility enhancer.
Preservatives & Antimicrobials 3 items
Benzyl Alcohol (0.9%)
Aromatic alcohol preservative in bacteriostatic water. Acts as antimicrobial agent by disrupting microbial cell membranes. Standard for multi-use vials.
Methyl / Propyl Parabens
Broad-spectrum antimicrobial preservatives effective against fungi and bacteria. Used in some peptide formulations where benzyl alcohol is incompatible.
Phenol (0.5%)
Bacteriostatic preservative used in certain injectable peptide formulations. Also acts as a conformational stabilizer for some peptide structures.
Counter Ions & Salt Forms 3 items
Trifluoroacetate (TFA)
Most common counter ion from RP-HPLC purification. Forms TFA salt with basic residues (Lys, Arg, His). May affect bioassay results and cell toxicity.
Acetate
Milder alternative to TFA obtained via ion exchange. Lower cytotoxicity, preferred for cell-based research assays and in vivo studies.
Hydrochloride (HCl)
Chloride salt form, sometimes used for improved stability or specific solubility profiles. Common in pharmaceutical-grade peptide preparations.
Chelating Agents 2 items
EDTA (Disodium)
Chelates divalent metal ions (Cu²⁺, Fe²⁺, Zn²⁺) that catalyze oxidative degradation of methionine and cysteine residues in peptides.
Citric Acid
Natural chelator with moderate metal-binding capacity. Dual function as buffer component and oxidation inhibitor in peptide formulations.
Antioxidants & Stabilizers 3 items
L-Methionine
Free methionine added as a sacrificial antioxidant. Preferentially oxidizes before methionine residues within the peptide chain.
Ascorbic Acid
Water-soluble antioxidant that scavenges reactive oxygen species. Used at low concentrations to prevent oxidative peptide degradation.
Polysorbate 20 / 80
Non-ionic surfactants that prevent surface adsorption and aggregation of peptides at air-liquid and container-liquid interfaces.
Preparation Tool
Reconstitution Calculator
Enter your target working concentration to calculate the exact solvent volume needed for this vial.
mg
Recommended solvents
Bacteriostatic Water Sterile Water for Injection Acetic Acid 0.1% Sodium Chloride 0.9%
Product Specs
Solubility Profile
WaterHighly soluble
Acidified WaterHighly soluble
DMSOHighly soluble
EthanolModerate
Lipid solventsPoor compatibility
Product Specs
Storage Specs
Lyophilized2–8°C preferred
Long-term−20°C recommended
Light SensitivityModerate
MoistureHigh sensitivity
StabilityStable when dry
ContainerSterile sealed vial
Literature
Research Citations
[1]Senior RM, Griffin GL, Mecham RP, Wrenn DS, Prasad KU, Urry DW. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J Cell Biol. 1984;99(3):870-874.
[2]Long MM, King VJ, Prasad KU, Freeman BA, Urry DW. Chemotaxis of fibroblasts toward nonapeptide of elastin. Biochim Biophys Acta. 1988;968(3):300-311.
[3]Tajima S, Wachi H, Uemura Y, Okamoto K. Modulation by elastin peptide VGVAPG of cell proliferation and elastin expression in human skin fibroblasts. Arch Dermatol Res. 1997;289(8):489-492.
[4]Ligorio C, Gomes RN, Skaria EE, Gupta P, Bhattacharjee S, Bhatt DL, Bhattacharjee B. Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers. ACS Appl Biomater. 2025;8(3):2340-2355.
[5]Pintea A, Rugina D, Bunea A, Socaciu C, Socaciu MA. Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence. Biomolecules. 2025;15(1):88.
Catalogue Pathway
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Important Notice
Research Use Only

AminoBox products are supplied for research, analytical, and laboratory use only. Product information is provided for educational and technical reference and does not constitute medical advice. Products are not intended to diagnose, treat, cure, or prevent any disease.

Property Specification
Product Name Biopeptide-EL
Alternate Names Palmitoyl Hexapeptide-12, Biopeptide EL™, Pal-VGVAPG
Content Amount 100 mg
Compound Class Synthetic lipopeptide
Physical Form Lyophilized peptide powder
Appearance White to off-white powder
Purity Typically ≥98% (HPLC dependent)
Research Category Cosmetic peptide / elastin signaling peptide
Primary Function Skin elasticity and extracellular matrix research

Molecular Information

Property Specification
Molecular Formula C38H68N6O8
Molecular Weight ~736.98 g/mol
CAS Number 171263-26-6
INCI Name Palmitoyl Hexapeptide-12
FDA UNII HO4ZT5S86C
Peptide Sequence Val-Gly-Val-Ala-Pro-Gly (VGVAPG)
Compound Type Palmitoylated signaling peptide
Structural Classification Elastin-derived matrikine analog

Structural Classification

Category Description
Compound Type Synthetic elastin-mimetic peptide
Functional Class Signal peptide / matrikine peptide
Biological Focus Extracellular matrix restructuring
Mechanistic Focus Fibroblast signaling and elastin support
Chemical Family Palmitoylated hexapeptides
Lipid Modification Palmitic acid conjugation for enhanced permeability

Mechanism Research Profile

Research Focus Description
Fibroblast Activation Studied for stimulation of fibroblast mobility and signaling
Elastin Support Mimics elastin peptide fragments involved in dermal repair
Collagen Research Investigated for collagen and glycosaminoglycan synthesis support
Skin Firmness Associated with elasticity and structural integrity research
Barrier Interaction Palmitoyl chain improves lipid membrane affinity
Matrix Remodeling Explored for extracellular matrix restructuring activity

Research Areas Commonly Associated

Research Area Focus
Cosmetic Peptide Research Anti-aging and skin-conditioning applications
Extracellular Matrix Research Collagen and elastin signaling pathways
Dermatological Research Skin elasticity and firmness studies
Peptide Delivery Research Lipophilic peptide transport mechanisms
Fibroblast Biology Cellular migration and tissue remodeling
Skin Barrier Science Lipid-peptide permeability optimization

Solubility Profile

Solvent Solubility
Water Limited
DMSO Soluble
Ethanol Moderately soluble
Glycols Good compatibility
Lipid Systems Enhanced compatibility due to palmitoylation

Storage Specifications

Parameter Recommendation
Short-Term Storage 2–8°C
Long-Term Storage -20°C preferred
Light Sensitivity Moderate
Moisture Sensitivity High
Stability Stable when lyophilized and protected from moisture
Container Type Sealed amber peptide vial

Technical Characteristics

Feature Notes
Delivery Format Lyophilized peptide powder (100 mg)
Structural Advantage Lipophilic palmitoyl chain enhances membrane interaction
Bioactivity Profile Elastin-mimetic signaling peptide
Sequence Origin Derived from repeating elastin fragment VGVAPG
Functional Target Fibroblast and extracellular matrix signaling
Stability Profile Improved stability versus non-lipidated peptides
Research Use Laboratory research only

Precision-Engineered Dermal Signaling Peptide

Biopeptide-EL, chemically identified as Palmitoyl Hexapeptide-12, is a sophisticated synthetic lipopeptide developed to emulate naturally occurring extracellular matrix signaling mechanisms involved in skin firmness, elasticity, and structural resilience. By conjugating a biologically active hexapeptide sequence with a palmitic acid lipid chain, this compound demonstrates enhanced transdermal affinity and improved integration within the skin’s lipid barrier.

Originally inspired by peptide domains found within elastin-associated proteins, Palmitoyl Hexapeptide-12 has become increasingly recognized within advanced cosmetic and longevity-focused formulations for its ability to support fibroblast communication and extracellular matrix optimization.

The Science Behind Palmitoyl Hexapeptide-12

Palmitoyl Hexapeptide-12 functions as a signal peptide, meaning it is designed to interact with dermal fibroblasts and encourage biochemical processes associated with tissue maintenance and structural protein synthesis.

The peptide sequence is believed to influence pathways associated with:

  • Collagen biosynthesis
  • Elastin fiber organization
  • Fibronectin expression
  • Dermal matrix remodeling
  • Skin tensile strength and elasticity

The palmitoyl modification substantially increases lipophilicity, allowing the peptide to more effectively penetrate the stratum corneum and maintain prolonged interaction within dermal environments.

Unlike abrasive resurfacing compounds or aggressive chemical interventions, Biopeptide-EL operates through cellular signaling modulation, supporting the skin’s intrinsic regenerative mechanisms rather than forcing inflammatory turnover.

Mechanistic Overview

Fibroblast Communication Support

Fibroblasts are responsible for synthesizing critical structural proteins within connective tissue. Palmitoyl Hexapeptide-12 is designed to mimic extracellular matrix fragments that naturally activate fibroblast response pathways involved in tissue repair and maintenance.

Extracellular Matrix Optimization

The extracellular matrix serves as the structural scaffold of the skin. Age-related degradation of collagen and elastin contributes to reduced firmness and elasticity. This peptide has been explored for its ability to support matrix organization and dermal density.

Lipid-Conjugated Delivery Enhancement

Attachment of a palmitic acid chain improves peptide affinity for lipid-rich skin environments, increasing topical compatibility and enhancing dermal bioavailability compared to non-lipidated peptide structures.

Research & Cosmetic Interest

Palmitoyl Hexapeptide-12 has generated substantial interest within cosmetic science due to its role in formulations targeting:

  • Fine lines and visible aging markers
  • Loss of elasticity
  • Skin texture irregularities
  • Environmental stress response
  • Dermal firmness support
  • Advanced anti-aging applications

Its biomimetic structure and non-invasive mechanism make it particularly attractive in modern peptide-based cosmetic development.

Why Researchers Choose Biopeptide-EL

Advanced Biomimetic Design

Engineered to emulate naturally occurring extracellular signalling fragments involved in dermal maintenance.

Enhanced Dermal Affinity

Palmitoylation improves lipid compatibility and supports effective topical integration.

High-Purity Manufacturing

Produced under stringent analytical standards with rigorous identity and purity verification.

Longevity-Focused Innovation

A next-generation cosmetic peptide is investigated for supporting youthful skin architecture and connective tissue integrity.

Disclaimer

This product is intended strictly for laboratory research, analytical, and cosmetic formulation applications only. Not intended to diagnose, treat, cure, or prevent any disease. This material is not approved for human consumption or pharmaceutical use.

Biopeptide-EL (Palmitoyl Hexapeptide-12) — Reference Table

Reference Source Information Provided Link
PubChem Molecular formula, molecular weight, peptide sequence, identifiers, structural data PubChem – Palmitoyl Hexapeptide-12
INCI Guide INCI classification, Biopeptide EL™ identity, functional overview INCI Guide – Biopeptide EL™
INCI Guide CAS number, peptide sequence, cosmetic activity profile INCI Guide – Palmitoyl Hexapeptide-12
Cosmetic Ingredients Guide Barrier support, elastin fragment activity, fibroblast research CI Guide – Palmitoyl Hexapeptide-12
INCI Beauty Cosmetic ingredient registry listing and INCI validation INCI Beauty – Palmitoyl Hexapeptide-12
PubChem Biological Description Sequence VGVAPG and palmitoylated peptide classification PubChem Biological Data